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Gorillas were presented with a wall-mounted device that spat out a peanut The animals were seen trying to suck out extra peanuts. Since first being introduced to the prototype device earlier this year, the scientists say the game has proved a hit with the troop of endangered western lowland gorillas.
Most children surpass the intelligence levels of chimpanzees before they reach four years old. A study conducted by Australian researchers in June tested children for foresight, which is said to distinguish humans from animals.
The experiment saw researchers drop a grape through the top of a vertical plastic Y-tube. They then monitored the reactions of a child and chimpanzee in their efforts to grab the grape at the other end, before it hit the floor.
Because there were two possible ways the grape could exit the pipe, researchers looked at the strategies the children and chimpanzees used to predict where the grape would go.
The apes and the two-year-olds only covered a single hole with their hands when tested. But by four years of age, the children had developed to a level where they knew how to forecast the outcome.
They covered the holes with both hands, catching whatever was dropped through every time. The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.
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I was not good with — I liked patients, but I was a little bit impatient with them. I then decided to go for a post-doc at Boston to Dana Farber, where I really learned the trade.
Clevers discovered similarities between the normal renewal of intestinal tissue and the onset of colon cancer. In he received a grant of two million euros from the Dutch Cancer Society KWF to study the function of stem cells in the normal intestines and in colon cancer, and in and he received ERC Advanced Investigator Grants.
In March , Clevers, who since had been a member of the Royal Netherlands Academy of Arts and Sciences, was elected its president, a position he assumed on 1 June of that year, succeeding Robbert Dijkgraaf.
In connection with his election to this position, he resigned as director from the Hubrecht Institute but kept his research lab there.
Since 1 June he is director Research of the Princess Maxima Center for paediatric oncology, located on the Utrecht campus close to the Hubrecht where he maintains his lab.
To summarise his scientific highlights, Hans Clevers identified the crucial downstream component of the Wnt signaling cascade, TCF, and the mechanism by which Wnt signals activate specific TCF target genes.
With these insights and in a collaboration with Bert Vogelstein, he proposed that in APC-deficient colon cancer, it is the inappropriate activation of the Wnt pathway that transforms cells.
He was the first to link Wnt signaling with adult stem cell biology, when he showed that TCF4 gene disruption leads to the abolition of crypt stem cell compartments of the gut.
He went on to show that the Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological crypt stem cell program.
He then described the Wnt target Lgr5 as a marker for adult stem cells including those of crypts. By the creation of several ingenious Lgr5-based transgenic mice, he established the intestinal crypt as one of the pre-eminent models to visualize and study adult stem cells in mammals.
He described several counter-intuitive characteristics for crypt stem cells: Lgr5 stem cells are abundant, they cycle rapidly, they divide symmetrically, and utilize their Paneth cell-daughters as their niche.
Similar results were then reported by him for multiple additional human and mouse tissues. This has opened ways to generate disease models directly from patients as well as avenues for regenerative medicine.
There was a first one, when I just started my lab, within the first few months we cloned the gene that they call TCF1 , T-cell factor 1, I used to be a T-cell embryologist when we first started out.
So in that paper we described cloning of this vector, which at that time maybe on the world scale was not great but for my own lab to clone this gene was my first thing I ever did alone.
When we realized this we started changing our model systems, we used to work on lymphocytes, and we changed it, first to frogs and flies, drosophila, where the Wnt pathway had been studied by many other people that way we could use assays of those people.
We then realized that in mammals Wnt signaling And we switched to the gut, we found that one of our knockouts, the TCF4 knockout, one of the four members of that family had no stem cells in the gut.
And in that same year we found in a collaboration with Bert Vogelstein that colon cancer comes about by the disregulation of TCF4, and those two phenomena are really linked.
May I emphasize, there are thousands of very competent embryologists, and they work on tiny details, and they fight over the smallest details, are extremely competent.
And we now can purify them in large numbers and study their characteristics. Clevers holds a dozen patents and was involved in the establishment of the biotech firm Ubisys, which, with Ton Logtenberg as CEO, later merged with Introgene to become Crucell.
Clevers also played a key role in the founding of Semaia Pharmaceuticals, which was later acquired by Hybrigenics SA. Clevers has more than publications to his name and has been cited a total of more than 62, times.
All his publications can be found on pubmed.Gute Unternehmensführung Pro vercelli von Https: Und genau das sollten sie nicht tun. Und genau das sollten sie nicht tun. Besides, the line about stelazine seems more a joke about being too fucked joe clever spiel alle fuГџball ligen deutschland eritrea rather than a comment about actual health risks of antipsychotics. Der Plumpsack geht um Verlag: